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Acetaminophen CAS#103-90-2

Analgesic & Antipyretic Effects‌：Effective pain relief and fever reduction.

Selective COX Inhibition‌：Modulates COX-2 more than COX-1 at high doses.

Metabolic Versatility‌：Generates reactive metabolites with diverse effects.

Animal Model Efficacy‌：Demonstrated therapeutic properties in vivo.

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Product Description

Products Description of Acetaminophen CAS#103-90-2

Acetaminophen is an analgesic/antipyretic that inhibits COX-2 (83%) and COX-1 (56%) at high 1,000 mg doses. Its toxic metabolite NAPQI causes liver injury by depleting glutathione, and it induces ferroptosis in mouse hepatocytes (reversible by ferrostatin-1). It remains effective for pain and fever relief in animal studies.

Product Applications of Acetaminophen CAS#103-90-2

Acetaminophen (Paracetamol, CAS# 103-90-2) is a non-anti-inflammatory antipyretic/analgesic. Comparable to aspirin in fever relief but weaker in pain relief, it is the top acetanilide derivative ideal for patients intolerant to carboxylic acid drugs. Used for colds and toothaches; also an organic intermediate, H₂O₂ stabilizer and photographic chemical component.

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Product Information

Parameters

Melting point	168-172 °C(lit.)
Boiling point	273.17°C (rough estimate)
density	1,293 g/cm3
vapor pressure	0.008Pa at 25℃
refractive index	1.5810 (rough estimate)
Fp	11 °C
storage temp.	Inert atmosphere,Room Temperature
solubility	ethanol: soluble0.5M, clear, colorless
form	Crystals or Crystalline Powder
pka	9.86±0.13(Predicted)
color	White
Odor	odorless
PH	5.5-6.5 (H2O, 20℃)(saturated solution)
PH Range	5.5 - 6.5 (H?O, 20 °C) (saturated solution)
explosive limit	15%(V)
Water Solubility	14 g/L (20 ºC)
Merck	14,47
BRN	2208089
BCS Class	3,4
Cosmetics Ingredients Functions	SKIN CONDITIONING
InChIKey	RZVAJINKPMORJF-UHFFFAOYSA-N
LogP	1.098 at 25℃
CAS DataBase Reference	103-90-2(CAS DataBase Reference)
IARC	3 (Vol. 50, 73) 1999
NIST Chemistry Reference	Acetaminophen(103-90-2)
EPA Substance Registry System	Acetaminophen (103-90-2)

Safety Information

Hazard Codes	Xn,T,F
Risk Statements	22-36/37/38-52/53-36/38-40-39/23/24/25-23/24/25-11
Safety Statements	26-36-61-37/39-22-45-36/37-16-7
RIDADR	UN 3077 9/PG III
WGK Germany	1
RTECS	AE4200000
Autoignition Temperature	540 °C
TSCA	Yes
HazardClass	9
PackingGroup	III
HS Code	29242930
Hazardous Substances Data	103-90-2(Hazardous Substances Data)
Toxicity	LD50 in mice (mg/kg): 338 orally (Starmer), 500 i.p. (Dahlin, Nelson)

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