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Paclitaxel CAS#33069-62-4

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  • Paclitaxel CAS#33069-62-4
  • Paclitaxel CAS#33069-62-4
  • Paclitaxel CAS#33069-62-4
  • Paclitaxel CAS#33069-62-4

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Paclitaxel CAS#33069-62-4

Paclitaxel promotes microtubule polymerization and stabilizes polymerized microtubules, a unique mechanism among known drugs.


It specifically binds to polymerized microtubules without affecting unpolymerized tubulin dimers.


Paclitaxel interferes with cellular functions by causing microtubule accumulation, effectively blocking cell division during mitosis.


Clinically effective for ovarian and breast cancer, with additional therapeutic effects on lung cancer, colorectal cancer, melanoma, head and neck cancer, lymphoma, and brain tumors.



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Product Description

Products Description of Paclitaxel CAS#33069-62-4

Paclitaxel is a diterpene extracted from yew bark. It uniquely promotes and stabilizes microtubule polymerization, binding only to formed microtubules. It disrupts cell division and arrests mitosis. Clinically, it is mainly used for ovarian and breast cancers, and also effective against lung, colorectal, melanoma, lymphoma and other malignancies.


Product Application of Paclitaxel CAS#33069-62-4

Paclitaxel is a natural broad-spectrum anticancer drug mainly for metastatic breast and ovarian cancers. It binds β-tubulin to stabilize microtubules, block depolymerization and arrest cell cycle at G2/M phase to suppress mitosis. It also acts effectively on human endothelial cells with low IC50 value.

Product Information

Parameters


Melting point213 °C (dec.)(lit.)
alphaD20 -49° (methanol)
Boiling point774.66°C (rough estimate)
density0.2
refractive index-49 ° (C=1, MeOH)
Fp9℃
storage temp.2-8°C
solubilitymethanol: 50 mg/mL, clear, colorless
formpowder
pka11.90±0.20(Predicted)
colorwhite
Water Solubility0.3mg/L(37 ºC)
λmax227nm(MeOH)(lit.)
Merck146982
BRN1420457
Stability:Stable. Incompatible with strong oxidizing agents. Combustible.
InChIKeyRCINICONZNJXQF-MZXODVADSA-N
LogP3.950 (est)
CAS DataBase Reference33069-62-4(CAS DataBase Reference)
EPA Substance Registry SystemPaclitaxel (33069-62-4)


Safety Information


Hazard CodesXn
Risk Statements37/38-41-42/43-62-68-40-48-20/21/22-68/20/21/22
Safety Statements22-26-36/37/39-45
RIDADR1544
WGK Germany3
RTECSDA8340700
F45951
HazardClass6.1(b)
PackingGroupIII
HS Code29329990
Hazardous Substances Data33069-62-4(Hazardous Substances Data)
ToxicityLD50 intraperitoneal in mouse: 128mg/kg

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