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β-Estradiol CAS#50-28-2

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  • β-Estradiol CAS#50-28-2
  • β-Estradiol CAS#50-28-2
  • β-Estradiol CAS#50-28-2
  • β-Estradiol CAS#50-28-2
  • β-Estradiol CAS#50-28-2

›

β-Estradiol CAS#50-28-2

Key Natural Estrogen Hormone: Estradiol is the most important and biologically active estrogen in the human body.


Naturally Derived Steroid Hormone: Primarily secreted by ovarian follicles, corpus luteum, and the placenta during pregnancy.


High Biological Activity: Exhibits strong physiological activity among all estrogen hormones.


Essential Role in Reproductive Health: Plays a central role in regulating female reproductive endocrine functions.



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Product Description

Product Description of β-Estradiol CAS#50-28-2

Estradiol is a steroid hormone primarily secreted by ovarian follicles, the corpus luteum, and the placenta during pregnancy. It is the most important and biologically active hormone among estrogens.


Product Application of β-Estradiol CAS#50-28-2

Estradiol, an estrogen drug, treats abnormal uterine bleeding, primary amenorrhea, menopause syndrome and prostate cancer. It regulates female genital development and secondary sexual features, and boosts mammary duct growth. High doses inhibit prolactin secretion to stop lactation.
It may cause nausea, vomiting and irregular bleeding. Caution is needed for liver and kidney dysfunction patients, and local genital use is prohibited.


Product Information

Parameters


Melting point178-179 °C(lit.)
alphaD25 +76 to +83° (dioxane)
Boiling point355.44°C (rough estimate)
density1.0708 (rough estimate)
refractive index80.4 ° (C=1, Dioxane)
Fp2℃
storage temp.room temp
solubilityPractically insoluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent), slightly soluble in methylene chloride.
pkapKa 10.71±0.02(H2O(0.1% p-dioxane) t=25±0.1 I=0.03(KCl))(Approximate)
formpowder
colorWhite to off-white
biological sourcesynthetic (organic)
Water SolubilitySoluble in dimethyl sulfoxide, ethanol , water, phosphate buffer saline, dimethyl formamide, acetone, dioxane and alkali hydroxides. Slightly soluble in vegetable oils.
Merck143703
BRN1914275
BCS Class1
Stability:Stable. Incompatible with strong oxidizing agents.
InChIKeyVOXZDWNPVJITMN-ZBRFXRBCSA-N
CAS DataBase Reference50-28-2(CAS DataBase Reference)
NIST Chemistry ReferenceEstra-1,3,5(10)-triene-3,17beta-diol(50-28-2)
EPA Substance Registry SystemEstradiol (50-28-2)


Safety Information


Hazard CodesT,Xn,F
Risk Statements60-61-45-63-64-40-36-20/21/22-11-48
Safety Statements53-22-36/37/39-45-36/37-26-16-36-20
RIDADR2811
WGK Germany3
RTECSKG2975000
F45879
HazardClass6.1
PackingGroupIII
HS Code29372390
Hazardous Substances Data50-28-2(Hazardous Substances Data)
ToxicityLD50 subcutaneous in rat: > 300mg/kg


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