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Carbamazepine CAS#298-46-4

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  • Carbamazepine CAS#298-46-4
  • Carbamazepine CAS#298-46-4
  • Carbamazepine CAS#298-46-4
  • Carbamazepine CAS#298-46-4
  • Carbamazepine CAS#298-46-4

›

Carbamazepine CAS#298-46-4

Broad Antiepileptic Efficacy: Carbamazepine is effective in managing psychomotor seizures, grand mal seizures, localized seizures, and mixed seizure types, offering broad therapeutic coverage.


Superior Peripheral Neuropathy Support: Compared with phenytoin sodium, it provides better therapeutic performance in the treatment of peripheral neuropathy.


Effective Neuralgia Treatment: It is widely used for the management of trigeminal neuralgia and glossopharyngeal neuralgia, delivering reliable pain-relief benefits.


Versatile Clinical Applications: In addition to epilepsy treatment, carbamazepine can also be applied in arrhythmia and diabetes insipidus management, highlighting its multifunctional pharmaceutical value.


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Product Description

Product Description of Carbamazepine CAS#298-46-4

Carbamazepine is a white or pale crystalline dibenzazepine antiepileptic agent. It works similarly to phenytoin sodium and is highly effective against psychomotor, generalized and partial seizures.

It shows superior effects on peripheral neuropathy, and is commonly used to relieve trigeminal and glossopharyngeal neuralgia. It is also applicable for arrhythmia and diabetes insipidus with wide clinical uses.

Product Application of Carbamazepine CAS#298-46-4

Carbamazepine is a dibenzazepine antiepileptic with effects similar to phenytoin sodium. It mainly treats psychomotor, generalized and partial seizures, and works better than phenytoin sodium for peripheral neuropathy, trigeminal and glossopharyngeal neuralgia. It is also used for arrhythmia and diabetes insipidus.
Its oral LD50 is 3750 mg/kg in mice and 4025 mg/kg in rats. Pharmacologically, it acts as a sodium channel inhibitor and binds to GABAA receptor benzodiazepine sites for medical and research use.


Product Information

Parameters


Melting point191-192 °C (lit.)
Boiling point378.73°C (rough estimate)
density1.1099 (rough estimate)
refractive index1.5906 (estimate)
Fp9℃
storage temp.2-8°C
solubility45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble29mg/mL
formCrystals
pka13.94±0.20(Predicted)
colorAlmost white
Water Solubilitypract. insoluble
Merck141781
BCS Class2
LogP2.45
CAS DataBase Reference298-46-4(CAS DataBase Reference)
NIST Chemistry ReferenceCarbamazepine(298-46-4)
EPA Substance Registry System5H-Dibenz[b,f]azepine-5-carboxamide (298-46-4)


Safety Information


Hazard CodesXn,T,F
Risk Statements42/43-22-20/21/22-39/23/24/25-23/24/25-11
Safety Statements37-24-22-36/37/39-36-45-36/37-16
RIDADRUN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany2
RTECSHN8225000
HS Code29339900
Hazardous Substances Data298-46-4(Hazardous Substances Data)
ToxicityLD50 orally in mice, rats: 3750, 4025 mg/kg (Stenger, Roulet)


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